We are pleased to announce that registration is now open for Diffraction Methods in Structural Biology 2026 (DiffMet2026), "Limitations & Expansions of Diffraction Methods in Structural Biology", with a registration deadline of April 30th, 2026. DiffMet2026 focuses on diffraction-based methods in structural biology, emphasizing a deep understanding of current methodological limitations and exploring strategies to extend or transcend them through innovation and multimodal approaches. Topics will include (but are not limited to): Time-resolved crystallography and its fundamental limits; microED, XFEL, neutron diffraction, and synchrotron-based methods; detector performance, radiation damage, and achievable resolution; integration of diffraction with complementary techniques; and the roles and limitations of AI in data processing and structure prediction. DiffMet2026 is accompanied by the Early Career Diffraction Method Seminar (ECS), "Growing the Future of Diffraction Methods". This seminar is primarily organized by and for early-career researchers (i.e., students, postdocs, and all those not yet in a permanent position). It will include talks by the early career attendees, as well as a poster session; please submit your oral/poster presentation abstracts by *April 30, 2026*. We will form the ECS scientific program on the basis of the submitted abstracts, so all diffraction methods-related topics are welcome! In addition to the scientific talks and posters by early career attendees, the ECS will also feature a keynote presentation and a career panel. The ECS will occur on July 19-20th; the main DiffMet2026 Conference then takes place from the evening of July 20th onwards. Participants are welcome to attend both parts of the meeting. The registration fee is €1200 and includes accommodation and all meals for both the ECS and the main meeting.